93 articles - From Friday Oct 24 2025 to Friday Oct 31 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Endoscopy |
|---|
| Comment on: "Performance of three major techniques for endoscopic submucosal dissection: a systematic review and network meta-analysis' - more questions than answers? |
| Comments on "Adenoma detection rate by colonoscopy in real-world population-based studies: a systematic review and meta-analysis". |
| Gut |
| Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis.
Approximately one in 10 people worldwide self-report NCGWS, with a female predominance and a significant association with psychological distress and irritable bowel syndrome. Our findings suggest positioning NCGWS within the spectrum of disorders of gut-brain interaction once organic pathologies have been excluded. |
| J Hepatol |
| Refining the Baveno VII criteria for clinically significant portal hypertension: an individual-patient data meta-analysis.
Baveno VII criteria for CSPH adequately classify patients across etiologies, except MASLD with obesity. Using a ≥75% risk threshold by ANTICIPATE models to detect CSPH improves global performance, including MASLD with obesity, supporting it can be a simpler way of predicting CSPH in clinical practice. Impact and implications This systematic review and meta-analysis confirm the validity for ruling out and ruling in CSPH in cACLD patients with the Baveno VII criteria. Using a threshold of ≥75% of the ANTICIPATE±NASH models, the global performance for detecting CSPH improves regardless of etiology. This represents a very practical approach for general hepatologists to select patients for prophylactic β-blocker therapy as its calculation relies on BMI, liver stiffness and platelet count with an online calculator. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| High Risk of Colorectal Cancer After High-Grade Dysplasia in Inflammatory Bowel Disease Patients.
The risk of synchronous and metachronous CRC after a diagnosis of high-grade dysplasia underlines the high-risk profile of this subgroup of patients with inflammatory bowel disease. The possible advantages of colon-sparing treatment should be balanced with the higher risk of metachronous CRC and the subsequent need for stringent endoscopic surveillance. |
| Inherited Genetic Risk of Liver Fibrosis in Lean Versus Nonlean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
The prevalence of significant fibrosis and the effect of GRS were similar in lean and nonlean MASLD, highlighting that lean MASLD patients may have a comparable risk to overweight and obese MASLD. |
| Research Communication: Real-World Clinical Experience With Seladelpar in Primary Biliary Cholangitis.
Biochemical response was achieved in 56.3% of patients and normalisation of alkaline phosphatase levels in 31.3% of patients after 1 month of treatment. This study demonstrates the efficacy of seladelpar as a second-line agent in a real-world clinical setting. |
| Research Communication: Risk of Tuberculosis With Advanced Therapies in 20,705 Patients With Inflammatory Bowel Diseases in Low Incidence Regions-A U.S. Claims-Based Study.
Adjusting for covariates, risk of tuberculosis was similar (HR, 1.16 [0.41-3.31]). In low incidence regions like USA, the incidence of tuberculosis after starting advanced therapies for IBD is very low, and comparable across advanced therapies. |
| Treatment Persistence, Normal Alkaline Phosphatase and Clinical Outcomes in Primary Biliary Cholangitis.
Treatment persistence is crucial in PBC as it is associated with normal ALP and significant improvement in clinical outcomes. Novel strategies and therapies are needed to enhance persistence and improve clinical benefits among individuals with PBC. |
| Unstable Recompensation: An Intermediate Subtype in Patients With HBV-Related Decompensated Cirrhosis.
Recompensation is not a uniform condition and should be further subclassified. Unstable recompensation is a distinct state with poorer survival than stable recompensation, yet better outcomes than ongoing decompensation. |
| Am J Gastroenterol |
| Low Sensitivity of Commercial Assays for Varicella Zoster Virus Seropositivity in Pediatric Patients with Inflammatory Bowel Disease.
As commercial VZV assays frequently fail to detect existing immunity in children with IBD, vaccination history should be used to assess VZV immunity. |
| Per-oral endoscopic myotomy-induced reduction of crural diaphragm contractility might contribute to development of post-procedural reflux esophagitis.
POEM can impair CD contraction, and weak CD contraction was associated with post-POEM RE. |
| The impact of E-Cigarettes and Heat-Not-Burn Tobacco on Postoperative Recurrence of Crohn's Disease: A Multicenter International Study.
HNBT, and possibly e-cigarettes, are associated with increased endoscopic recurrence of CD compared to non-smoking. |
| Clin Gastroenterol Hepatol |
| Enhanced Prediction of HBV-Related HCC Using aMAP and Liver Stiffness Assessed by Vibration-Controlled Transient Elastography.
The integration of aMAP score with LS measurements significantly improved HCC risk prediction in CHB patients receiving antiviral therapy. This combined model may enable more precise risk stratification and personalized surveillance strategies. |
| Endosc Int Open |
| Comparing peroral endoscopic myotomy and laparoscopic Heller myotomy for esophageal motility disorders: Nationwide cohort study.
In this nationwide cohort, LHM remained more commonly performed in the United States. However, our results confirm that POEM demonstrated favorable outcomes in management of esophageal motility disorders. |
| Cricopharyngeal myotomy using grasping scissors: Benefits of peroral endoscopic myotomy in symptomatic Zenker's diverticulum.
In patients with treatment-naïve ZD, the Clutch Cutter technique is safe, fast, and provides durable symptom remission. |
| Diagnostic accuracy and interobserver agreement for prediction of gastric preneoplastic lesions with fourth-generation endocytoscopy: Pilot study.
New-generation endocytoscopy has potential to identify GPL with high diagnostic accuracy, reliability, and reproducibility. Training and clinical experience with endocytoscopy are required to maximize diagnostic performance. |
| Elective colectomy for treatment of benign colon polyps: National surgical trends, outcomes, and cost analysis.
Rates of colectomy for benign adenomas significantly increased from 2000 to 2014. Colectomy was associated with significant mortality, morbidity, and cost. Development of strategies to improve endoscopic management of benign large colon neoplasms is urgently needed. |
| Endoscopic ultrasound-guided radiofrequency ablation for treatment of pancreatic neuroendocrine tumors: Multicenter prospective study.
Our prospective international multicenter study demonstrated that EUS-RFA is highly safe and effective for the treatment for both F- and NF-PanNETs. |
| Enhancing comprehensive genome profiling of liver tumors using endoscopic ultrasound-guided fine-needle biopsy.
EUS-FNB is highly effective for obtaining ideal samples for CGP and achieving an accurate histological diagnosis. The 22G and 19G needles were significantly superior to 25G needles, thus emphasizing their importance in precision medicine. |
| Therapeutic potential of gastro-gastric fistulas created via lumen-apposing metal stents for nutritional deficiencies after roux-en-y gastric bypass.
Temporary partial-reversal of RYGB using a LAMS improves key nutritional parameters without compromising metabolic benefits of RYGB. These findings may support a therapeutic role for iatrogenic GG fistulas as a minimally invasive option for RYGB patients with refractory nutritional deficiencies. |
| Endoscopy |
| Individuals with polyps ≥10mm without other high-risk features have a similarly low post-colonoscopy colorectal cancer risk as those with no polyps.
PCCRC-risk 5 years after baseline colonoscopy within individuals with polyps ≥10mm without other high-risk features is not significantly different from individuals without polyps at baseline. Lengthening surveillance intervals would affect 79% of high-risk individuals with ≥10mm polyps as their sole high-risk feature, and 46% if limited to those with 10-20mm polyps. |
| Long-term follow-up results after the recanalization of completely obstructed benign biliary strictures using magnetic compression anastomosis.
MCA is an effective nonsurgical treatment option for patients with completely occluded BBS refractory to standard interventions, demonstrating a low recurrence rate in long-term follow-up. |
| Single-Use versus Reusable Gastroscopes for the initial Assessment of patients with Upper Gastrointestinal Bleeding: A Prospective Randomised Non-Inferiority Trial.
Results 148 patients were included between 03/2023 and 04/2024. A complete assessment of the UGIT was achieved in 72 of 74 patients with the SUG and in 71 of 74 patients with the RUG, (97.3% vs 95.9%; p SUG are non-inferior to RUG in the complete assessment of the UGIT in patients with signs of upper GIB, however, a significantly higher rate of bleeding site identification, superior visualization quality, greater acceptance by endoscopists, and a trend toward more effective therapeutic performance was achieved with RUG. |
| Gastroenterology |
| Targeting Mutual Dependence of Phosphatidylinositol-3-Kinase α/δ and Small Ubiquitin-Like Modifier Signaling in Pancreatic Cancer.
Our study introduces a novel rational combination therapy in PDAC. Dual targeting of PI3Kα/δ and SUMO signaling bears potential for clinical translation. |
| Validation of a Serum-Based Biomarker Signature for Detection of Early-Stage Pancreatic Ductal Adenocarcinoma.
These findings indicate that PancreaSure is a high-performing biomarker test to aid in the detection of early-stage PDAC. Overall, this work represents an important step toward improving early-stage diagnostic success. |
| Gastrointest Endosc |
| Contrast enhanced EUS versus conventional EUS guided fine needle biopsy with macroscopic on-site evaluation for solid pancreatic lesions: a multicenter randomized trial.
In this multicenter study, CE-EUS and conventional EUS guided FNB with MOSE had similarly low false negative rates and high diagnostic accuracies for SPL. Routine use of CE-EUS did not further improve FNB yield in SPL when dedicated FNB needles were used. |
| Gut |
| Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort.
We propose broad, potent serum Fc-mediated effector functions and neutralisation and a broad anti-E1E2 antibody epitope specificity as ingredients of HCV-protective immunity towards which vaccination approaches should aim. |
| Dynamic urinary proteomics integrates single-cell and spatial transcriptomics to reveal tumour microenvironment and predict immunotherapy response in biliary tract cancer.
This study pioneers the application of urinary proteomics in immuno-oncology, providing a non-invasive approach to predict and monitor ICI responsiveness, while offering mechanistic insights into TME dynamics in BTC. |
| EASL 2025 indications revisited: phase-specific outcomes with and without nucleos(t)ide analogue therapy in chronic hepatitis B virus infection.
NAs therapy was associated with reduced risks of cirrhosis and HCC in HBeAg-positive individuals with high replicative or impending phase transition phenotypes, supporting the expansion of chronic HBV infection treatment criteria. |
| First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia.
This GWAS led to the identification of SNPs, cellular mechanisms and cell types that are involved in IA aetiopathology. |
| SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL.
Our findings establish SIRT6 as an oncogenic driver in ICC by orchestrating glutamine metabolic reprogramming and highlight the SIRT6-GLUL axis as a potential therapeutic target for ICC. |
| Hepatology |
| Endothelial-to-mesenchymal transition: A targetable mechanism that contributes to portal vein thrombosis in cirrhosis.
In cirrhosis, the portal vein endothelium undergoes maladaptive remodeling marked by eccentric intimal hyperplasia, driven by ECM accumulation and infiltration of inflammatory and myofibroblast-like cells. This process narrows the lumen and may promote PVT. EndMT plays a key role in this transformation and emerges as a novel and promising therapeutic target. Notably, statins can attenuate EndMT, highlighting its potential in PVT treatment. |
| J Hepatol |
| Utilization of liver grafts obtained from donation after medical assistance in dying: A Canadian multicenter experience.
Liver grafts from MAiD donor may be successfully transplanted with comparable outcomes to DCD-III and contributed to a 21.8% increase of DCD activity across Canada. These results encourage additional efforts to consider MAiD as a valuable additional source of liver grafts. Further studies and larger clinical experience are necessary to validate these results. Impact and implications Liver transplantation with grafts following medical assistance in dying has satisfactory patients and graft survival rates, and the incidence of major post-operative events and complications were comparable with the standard circulatory death donors.Cumulatively, medical assistance in dying donors contributed to a significant increase of the donation after circulatory death liver transplantation activity in Canada by 21.8% in a 7-year period.This data encourages to pursue donation following medical assistance in dying as a valuable additional source of grafts, also allowing to fulfill patient's wishes to donate their organs and help others. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
|---|
| Blue Notes. |
| Strategies to Promote Health Equity in Professional Society Clinical Guidance in Gastroenterology. |
| J Hepatol |
| BCLC strategy for prognosis prediction and treatment recommendations: The 2025 update.
These updates are particularly important for clinicians, tumor boards, and guideline developers, as well as for patients and caregivers who face complex choices in real-world practice. In practical terms, the prognostic capacity of BCLC is embedded within person-centered decision-making, fostering iterative treatment planning and laying the foundation for future studies assessing the clinical impact of CUSE, while acknowledging the need for validation and variability in implementation across healthcare settings. |
| Closing the Gap: Why Liver Health Must Be Central to the United Nations Political Declaration on Non-Communicable Diseases. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Letter to the Editor. |
| Clin Gastroenterol Hepatol |
| Isolated Esophageal Lichen Planus Effectively Treated With Topical Tacrolimus. |
| Endosc Int Open |
| Amber-red color imaging for enhanced visualization and hemostasis during rectal endoscopic submucosal dissection. |
| Real-time probe-based confocal laser endomicroscopy visualization of dual differentiation features in mixed-type gastric adenocarcinoma. |
| Safe endoscopic colorectal stenting using a biliary balloon catheter: Balloon anchoring method. |
| Stent-in-stent deployment across the papilla for malignant hilar biliary obstruction using novel slim multi-hole metal stents. |
| Endoscopy |
| A duodenal tumor near the major duodenal papilla treated using a new thin therapeutic endoscope following pancreatic and biliary stenting. |
| Clinical and environmental implications of a high-density clip closure after endoscopic submucosal dissection: is it worth it? |
| Digital subtraction pancreatography enhances ductal visualization in high grade pancreatic intraepithelial neoplasia. |
| Endoscopy E-Videos - recently published. |
| Gel immersion transpapillary stone removal for recurrent choledocholithiasis. |
| Implementing a "resect and discard" strategy using a characterization mobile app: toward a more sustainable endoscopy practice. |
| Is the underwater injection endoscopic mucosal resection technique suitable for T1 colorectal cancer? |
| Methodological considerations for recurrence analysis. |
| Mucosal incision assisted unroofing technique for endoscopic full thickness resection of a gastric subepithelial lesion. |
| Successful removal of a fractured guidewire from the main pancreatic duct using a novel endoscopic device. |
| Underwater peroral endoscopic myotomy improves visualization and reduces adverse events in a high-risk patient with type III achalasia. |
| Gut |
| Cause of a colorectal polyp in the caecum. |
| Robot versus conventional ESD for colonic lesions: results from a randomising model trial. |
| Hepatology |
| Letter to the Editor: Are we overestimating LSM-based HCC risk in MASLD? Addressing immortal time bias. |
| Letter to the Editor: Rethinking prognostic endpoints in alcohol-associated hepatitis. |
| Letter to the Editor: The missing link-return to drinking as a composite endpoint component requires deeper alcohol use disorder characterization. |
| Yttrium-90 superiority in hepatocellular carcinoma downstaging: Treatment effect or selection bias? |
Letters to the editors and authors’ replies
| Gastroenterology |
|---|
| A Critical View on the Differentiation Pathway of BEST4<sup>+</sup> Cells in Human Colonic Epithelium. |
| Acupuncturist Roles in the Perioperative Period: How Far Are We From Clinical Integration? |
| Addressing Limitations in the Multimetric Classification Tree Model for Timed Barium Esophagram Interpretation. |
| Assessment of Methods in AOH1996 Studies for Pancreatic Ductal Adenocarcinoma Therapy. |
| Comments on "Coaching in Gastroenterology Training". |
| Critical Role of Fucosyltransferase VII in Glycosylation-Dependent Regulatory T Cell Function in Inflammatory Bowel Disease. |
| Electroacupuncture for Postoperative Ileus: Critical Gaps in Mechanistic Validation and Clinical Relevance. |
| Electroacupuncture in Postoperative Ileus: Bridging Traditional Chinese and Western Medicine for Enhanced Recovery. |
| Human-AI Interaction and Global Disparities in the Clinical Implementation of Medical AI. |
| Improving Precision in Crohn's Disease: Insights from the VCE Trial. |
| Is It Just About How Much You Drink? The Overlooked Role of Drinking Patterns in Fatty Liver Disease. |
| Long-Term Implications of Macrophage Modulation in Intestinal Regeneration: Balancing Tissue Repair and Cancer Risk. |
| Management of Postoperative Ileus. |
| Methodological and Clinical Perspectives on a Study of Electroacupuncture After Laparoscopic Gastrectomy for Gastric Cancer. |
| Names Matter (and Other Matters). |
| Regarding "Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer". |
| Rethinking "Normal": Methodological Gaps in Defining Eosinophil Baselines in the Adult Gastrointestinal Tract. |
| Revolutionizing Gastroenterology with Artificial Intelligence: Clinical Insights and Challenges. |
| Gastrointest Endosc |
| Automated bowel preparation scoring: commentary on Open-Source Automatic Bowel Preparation Scale and frame-level challenges. |
| Cold versus hot-snare endoscopic submucosal resection for colorectal polyps: clinical variables that warrant further stratification. |
| Endoscopic resection for small rectal neuroendocrine tumors: stretching the budget with band ligation. |
| Is the "distinct border + II/IIIL pit pattern" truly an absolute indication for endoscopic resection in ulcerative colitis-associated neoplasia? |
| Lymph node metastasis risk stratification in rectal neuroendocrine tumors: critical factors still to be elucidated in the pursuit of precision. |
| Reconsidering margin adequacy and bias in endoscopic resection of rectal neuroendocrine tumors. |
| Salvage colorectal endoscopic submucosal dissection: key questions and future directions behind a significant advance. |
| Stacking the odds: challenging the hierarchy in pancreas divisum detection. |
| Through-the-scope catheter-based EUS during double-balloon enteroscopy for small-bowel Crohn's disease: key evaluation of the effectiveness and accuracy. |
| Whether the long-term success of peroral endoscopic myotomy with concomitant endoscopic fundoplication can be replicated. |
| Gut |
| Pharmacological trials of early intervention in predicted severe acute pancreatitis: implications for therapeutic window and core outcome set. |
| Profiles of quantitative hepatitis B surface antigen in patients with chronic hepatitis B. |
| Sampling the incisura angularis for the assessment of gastritis: preliminary insights from a systematic review. |